AGENTIC-SYSTEMSMarch 20, 20261 min read7 views

The Validity Gap in Health AI Evaluation: A Cross-Sectional Analysis of Benchmark Composition

A cross-sectional analysis reveals a structural 'validity gap' in health AI benchmarks, which often fail to represent complex clinical scenarios, vulnerable populations, and real-world medical needs.

Computer Science > Artificial Intelligence

Title:The Validity Gap in Health AI Evaluation: A Cross-Sectional Analysis of Benchmark Composition

Background: Clinical trials rely on transparent inclusion criteria to ensure generalizability. In contrast, benchmarks validating health-related large language models (LLMs) rarely characterize the "patient" or "query" populations they contain. Without defined composition, aggregate performance metrics may misrepresent model readiness for clinical use.

Methods: We analyzed 18,707 consumer health queries across six public benchmarks using LLMs as automated coding instruments to apply a standardized 16-field taxonomy profiling context, topic, and intent.

Results: We identified a structural "validity gap." While benchmarks have evolved from static retrieval to interactive dialogue, clinical composition remains misaligned with real-world needs. Although 42% of the corpus referenced objective data, this was polarized toward wellness-focused wearable signals (17.7%); complex diagnostic inputs remained rare, including laboratory values (5.2%), imaging (3.8%), and raw medical records (0.6%). Safety-critical scenarios were effectively absent: suicide/self-harm queries comprised <0.7% of the corpus and chronic disease management only 5.5%. Benchmarks also neglected vulnerable populations (pediatrics/older adults <11%) and global health needs.

Conclusions: Evaluation benchmarks remain misaligned with real-world clinical needs, lacking raw clinical artifacts, adequate representation of vulnerable populations, and longitudinal chronic care scenarios. The field must adopt standardized query profiling--analogous to clinical trial reporting--to align evaluation with the full complexity of clinical practice.

Source: arXiv cs.AI Recent

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