Group averages obscure how an individual's brain controls behavior: study

Studying cognition by averaging data from many people’s brain scans hides how individuals use their brains, new Stanford Medicine research has shown.

In particular, children who struggle with goal-oriented tasks show distinct patterns of brain activity when their data is analyzed individually, rather than as part of a group of kids with mixed abilities. The findings, which have implications for understanding how the brain works in such conditions as attention-deficit/hyperactivity disorder, will be published April 27 in Nature Communications.

“Investigating how dynamics unfold within individual brains can provide significant insights into the neuroscience of individual differences and help us tackle questions that cannot be answered using conventional approaches,” said Percy Mistry, PhD, a research scholar in psychiatry and behavioral sciences, and a lead author of the study.

Mistry shares lead authorship with Nicholas Branigan, MS, a research data analyst in psychiatry and behavioral sciences. The senior author is Vinod Menon, PhD, a professor of psychiatry and behavioral sciences and the Rachael L. and Walter F. Nichols, MD, Professor.

The research evaluated inhibitory cognitive control — the process by which the brain suppresses distracting or irrelevant information while someone completes a task — in more than 4,000 children. The researchers compared results obtained by averaging brain-scan data of children against results obtained by analyzing the temporal dynamics in each child as they performed repetitions of the same task.

“Our study provides theoretical support for a growing movement toward personalization in human neuroscience, psychology and psychiatry,” Branigan said.

This approach was also able to identify subgroups of children with different levels of cognitive control and performance monitoring, or the ability to modify one’s strategy after making an error.

For example, children with good cognitive control and performance monitoring and those with poor cognitive control and performance monitoring showed quite different — and often opposite — brain dynamics.

Noting that studies connecting behavior to brain activity typically draw their conclusions from averaging groups’ data, Menon said, “Our study clearly shows that group averages can fundamentally mislead us about how the brain dynamically regulates behavior.”

A clue from the speed-accuracy trade-off

Psychologists have long known that behaviors that seem linked in a certain way when you study them in groups may not be related in the same way in individuals. The best example is the speed-accuracy trade-off: If you ask a group of people to do a task such as quickly solving arithmetic problems, the faster people tend to be more accurate. However, if you ask one individual to go faster, their accuracy will likely decline — or, if you ask one person to be more accurate, they’ll probably slow down.

Experts have wondered if a similar phenomenon plays out in hidden ways inside the brain.

The Stanford Medicine team looked at brain scan data from kids doing a task that measures their inhibitory control. To focus on a job or goal, a person must suppress the urge to pay attention to distractions and things that aren’t relevant while inhibiting actions or impulsive behaviors that are contradictory to reaching their goal.

Inhibitory control gets the job done. Poor inhibitory control is a hallmark of several psychiatric diagnoses, including ADHD, bipolar disorder and addiction. Understanding how inhibitory control normally works — and how it goes awry — could help guide the development of better behavioral therapies for these conditions.

Individual results going a different way

The research team analyzed data from more than 4,000 children, all 9 or 10 years old, that was collected as part of the baseline visit for the Adolescent Brain and Cognitive Development study, a long-term study tracking brain maturation into early adulthood.

The children’s brains were scanned via functional magnetic resonance imaging while they completed an activity designed to assess inhibitory control. Called the stop-signal task, the activity consists of pressing a button in response to prompts on a screen. Every time the child saw “Go” on the screen, they were asked to press the button as quickly as possible. Occasionally, the “Go” sign was immediately followed by an additional “Stop” sign. The children were supposed to avoid pressing the button when they saw this infrequent, unpredictable Stop cue.

The research team examined aspects of what the brain was doing during the task on every trial — both when comparing the children with one another and when analyzing several repetitions of the task by the same person.

The researchers found several brain-behavior links that were different within individuals than in the group as a whole.

For instance, when analyzing average trends in groups of children, slower reaction times to the “Go” signal were linked to increased activity in many brain regions, including the default mode network, which is involved in daydreaming, thoughts about oneself and mind-wandering.

However, when an individual had a slower reaction time to the “Go” signal, activity decreased in the default mode network — the opposite of the group-level pattern.

“Group-level associations substantially mischaracterize the neural dynamics governing processing speed at the individual level,” the research team wrote.

“Investigating how dynamics unfold within individual brains can provide significant insights into the neuroscience of individual differences and help us tackle questions that cannot be answered using conventional approaches.”

—Percy Mistry

The researchers also developed a mathematical model that enabled them to study how the children adapted their reactions during several repetitions of the stop-signal task. Children with adaptive (good) regulation showed faster stopping reactions as they got further past the first “Stop” signal, correctly anticipating that each subsequent trial was more likely to be another “Stop.” Children with maladaptive reactions showed the opposite pattern, indicating decreasing expectancy of a second “Stop” signal. This difference shows up in the scans, manifesting as opposite reactions in activity in specific brain areas among the children with adaptive and maladaptive regulation.

The analysis also showed that some effects seen in the entire group of children were driven solely by children in one of the groups; in other words, the average results obscured what happened in many children’s brains.

Various pathways

The researchers also found that cognitive control has multiple components, which are orchestrated by different parts of the brain, including proactive control (preparing to stop) and reactive control (actually stopping). The brain regions used in these sub-processes are not always talking to each other in the same way in kids with stronger versus kids with weaker cognitive control.

“When children are weaker at cognitive control, they may be able to compensate for that with a more proactive approach or an alternate cognitive pathway,” Mistry said. “That’s interesting because it moves the dialogue away from cognitive control being a static capacity that children have, to something that can perhaps be regulated or driven in multiple ways.”

The findings may prove useful in designing new approaches to help children with ADHD improve in the types of behavior regulation that are hard for them, Mistry added. “If you’re looking at strategies in the classroom, this data points to the fact that inhibitory cognitive control is not a single capacity. There are multiple pathways involved, and perhaps students can learn to engage specific pathways to be more proactive about their inhibitory control approach,” he said.

Not only does the study open new possibilities for understanding human variability in brain function, but it should encourage neuros