Didgeridoo playing as alternative treatment for obstructive sleep apnea(2006)

Abstract

Objective To assess the effects of didgeridoo playing on daytime sleepiness and other outcomes related to sleep by reducing collapsibility of the upper airways in patients with moderate obstructive sleep apnoea syndrome and snoring.

Design Randomised controlled trial.

Setting Private practice of a didgeridoo instructor and a single centre for sleep medicine.

Participants 25 patients aged > 18 years with an apnoea-hypopnoea index between 15 and 30 and who complained about snoring.

Interventions Didgeridoo lessons and daily practice at home with standardised instruments for four months. Participants in the control group remained on the waiting list for lessons.

Main outcome measure Daytime sleepiness (Epworth scale from 0 (no daytime sleepiness) to 24), sleep quality (Pittsburgh quality of sleep index from 0 (excellent sleep quality) to 21), partner rating of sleep disturbance (visual analogue scale from 0 (not disturbed) to 10), apnoea-hypopnoea index, and health related quality of life (SF-36).

Results Participants in the didgeridoo group practised an average of 5.9 days a week (SD 0.86) for 25.3 minutes (SD 3.4). Compared with the control group in the didgeridoo group daytime sleepiness (difference -3.0, 95% confidence interval -5.7 to -0.3, P = 0.03) and apnoea-hypopnoea index (difference -6.2, -12.3 to -0.1, P = 0.05) improved significantly and partners reported less sleep disturbance (difference -2.8, -4.7 to -0.9, P < 0.01). There was no effect on the quality of sleep (difference -0.7, -2.1 to 0.6, P = 0.27). The combined analysis of sleep related outcomes showed a moderate to large effect of didgeridoo playing (difference between summary z scores -0.78 SD units, -1.27 to -0.28, P < 0.01). Changes in health related quality of life did not differ between groups.

Conclusion Regular didgeridoo playing is an effective treatment alternative well accepted by patients with moderate obstructive sleep apnoea syndrome.

Trial registration ISRCTN: 31571714.

Introduction

Snoring and obstructive sleep apnoea syndrome are two highly prevalent sleep disorders caused by collapse of the upper airways.1,2,3 The most effective intervention for these disorders is continuous positive airway pressure therapy, which reduces daytime sleepiness4 and the risk of cardiovascular morbidity and mortality in the most severely affected patients (apnoea-hypopnoea index (measured as episodes per hour) > 30).5 For moderately affected patients (apnoea-hypopnoea index 15-30) who complain about snoring and daytime sleepiness, however, continuous positive airway pressure therapy may not be suitable and other effective interventions are needed.1,6,7

AS, a didgeridoo instructor, reported that he and some of his students experienced reduced daytime sleepiness and snoring after practising with this instrument for several months. In one person, the apnoea-hypopnoea index decreased from 17 to 2. This might be due to training of the muscles of the upper airways, which control airway dilation and wall stiffening.8,9,10 We tested the hypothesis that training of the upper airways by didgeridoo playing reduces daytime sleepiness in moderately affected patients.

Methods

Participants and methods

We included German speaking participants aged > 18 years with self reported snoring and an apnoea-hypopnoea index of 15-30 (determined by a specialist in sleep medicine within the past year). Exclusion criteria were current continuous positive airway pressure therapy, use of drugs that act on the central nervous system (such as benzodiazepines), current or planned intervention for weight reduction, consumption of ≥ 14 alcoholic drinks a week or ≥ 2 a day, and obesity (body mass index ≥ 30 kg/m2).

We recruited patients at our study centre (Zuercher Hoehenklinik Wald, Wald, Switzerland) and one private practice in Zurich. Physicians at the study centre assessed all potential participants for eligibility. Those willing to participate provided written informed consent. After study enrolment, all patients completed a baseline assessment.

We randomised enrolled patients into an intervention group with didgeridoo training or a control group. We used STATA software (STATA 8.2, College Station, Tx) to generate the randomisation list (ralloc command) with stratification for disease severity (apnoea-hypopnoea index 15-21 or 22-30 and Epworth score < 12 or ≥ 12). The randomisation list was concealed from the recruiting physicians and the didgeridoo instructor in an administrative office otherwise not involved in the study. We used a central telephone service, which the didgeridoo instructor used to obtain group allocation.

Intervention and control

Participants in the intervention group started their didgeridoo training after the instructor received group allocation. The instructor (AS) gave the first individual lesson immediately after randomisation. In the first lesson, participants learnt the lip technique to produce and hold the keynote for 20-30 seconds. In the second lesson (week 2) the instructor explained the concept and technique of circular breathing. Circular breathing is a technique that enables the wind instrumentalist to maintain a sound for long periods of time by inhaling through the nose while maintaining airflow through the instrument, using the cheeks as bellows. In the third lesson (week 4) the didgeridoo instructor taught the participants his technique to further optimise the complex interaction between the lips, the vocal tract, and circular breathing so that the vibrations in the upper airway are more readily transmitted to the lower airways.11 In the fourth lesson, eight weeks after randomisation, the instructor and the participants repeated the basics of didgeridoo playing and made corrections when necessary. Participants had to practise at home for at least 20 minutes on at least five days a week and recorded the days with practice and the practice time (answer options for 0, 20, or 30 minutes).

Participants received a standardised acrylic plastic didgeridoo that was developed by the instructor in collaboration with Creacryl GmbH (Ebmatingen, Zurich, Switzerland, and costs €80 (£43; $94), fig 1). The didgeridoo is 130 cm long with a diameter of 4 cm and an elliptical embouchure with a diameter of 2.8-3.2 mm. Acrylic didgeridoos are easier for beginners to learn on than conventional wooden didgeridoos.

Participants in the control group remained on a waiting list to start their didgeridoo training after four months. They were not allowed to start didgeridoo playing during these four months.

Outcome measures

Our primary outcome was daytime sleepiness as measured by the Epworth scale, which has been validated in German speaking patients.12 Scores range from 0 (no daytime sleepiness) to 24, and scores > 11 represent excessive daytime sleepiness.

Secondary outcomes included three additional sleep related outcomes measures: the apnoea-hypopnoea index, the Pittsburgh quality of sleep index, and a partner's rating for sleep disturbance.

The cardiorespiratory sleep study was performed at the sleep laboratory of the study centre with a computerised system (SleepLab Pro, Jaeger, Hoechberg, Germany), according to the guidelines of the German Society for Sleep Medicine.13 We measured airflow using nasal and oral thermistors and a nasal canula with a differential pressure flow sensor. We defined episodes of apnoea as cessation of airflow of > 10 seconds with decrements of blood oxygen saturation of ≥ 4%. Hypopnoea was defined as a reduced airflow for at least 10 seconds with decrements of blood oxygen saturation of ≥ 4% or waking, or both. The person who analysed the sleep recordings was blinded to group allocation throughout the trial.

The Pittsburgh quality of sleep index is a self administered questionnaire with 19 items to determine sleep quality, latency, duration, and disturbance within the past four weeks.14